In the space environment, semiconductors can be exposed to various radiation sources depending on mission conditions. Depending on the type, energy, and speed of radiation, different damage mechanisms occur. These can be broadly categorized into Total Ionizing Dose (TID) effects due to radiation accumulation and Single Event Effects (SEE) caused by the penetration of radiation particles. We...
In the space environment, changes in factors such as blood circulation under microgravity conditions can potentially result in modifications to the pharmacokinetic aspects of drug utilization, impacting drug absorption, distribution, metabolism, and excretion within the body. Nevertheless, assessing these alterations in a terrestrial setting can be challenging. Thus, there is a need for...
This study investigates the effect of mixing ratios on the compatibility and binding energy of polyvinylpyrrolidone (PVP) and polyacrylic acid (PAA) in polymer composites for radiation treatment using molecular dynamics (MD) and Monte Carlo (MC) simulations. Five simulation models were constructed by varying the composition ratio of PVP and PAA (1/9, 3/7, 5/5, 7/3, 9/1), and the solubility...
The tumor microenvironment (TME) consisting of blood and lymphatic vessels, fibroblasts, immune cells, and extracellular matrix (ECM) is a critical factor determining prognosis of anti-cancer drug treatment. Most of all, vasculature and ECM structures are the most influential factors in TME. The abnormal, tortuous and leaky tumor vasculature structure reduces chemical drug delivery to target...
