15th Geant4 Space Users Workshop

Session

Lightening talks

7 Dec 2023, 11:50

Hyatt Place Pasadena

5. Radiation damage simulation and tolerance technology research for TID effects and SEE of semiconductors

Minwoong Lee (Korea Atomic Energy Research Institute)

07/12/2023, 11:50

In the space environment, semiconductors can be exposed to various radiation sources depending on mission conditions. Depending on the type, energy, and speed of radiation, different damage mechanisms occur. These can be broadly categorized into Total Ionizing Dose (TID) effects due to radiation accumulation and Single Event Effects (SEE) caused by the penetration of radiation particles. We...

6. Physiologically based Pharmacokinetic Modeling and Simulation for Astro-Pharmacokinetic Analysis and Prediction in the Space environment

Kyeong-Ryoon Lee (Korea Research Institute of Bioscience and Biotechnology)

07/12/2023, 12:00

In the space environment, changes in factors such as blood circulation under microgravity conditions can potentially result in modifications to the pharmacokinetic aspects of drug utilization, impacting drug absorption, distribution, metabolism, and excretion within the body. Nevertheless, assessing these alterations in a terrestrial setting can be challenging. Thus, there is a need for...

7. Molecular simulation study on the miscibility of polymer composites for radiation processing

Hui-Jeong Gwon (Korea Atomic Energy Research Institute)

07/12/2023, 12:10

This study investigates the effect of mixing ratios on the compatibility and binding energy of polyvinylpyrrolidone (PVP) and polyacrylic acid (PAA) in polymer composites for radiation treatment using molecular dynamics (MD) and Monte Carlo (MC) simulations. Five simulation models were constructed by varying the composition ratio of PVP and PAA (1/9, 3/7, 5/5, 7/3, 9/1), and the solubility...

20. Development of a biomimetic microenvironment chip for the detection of biochemical responses expected in the body

Dr Kihwan Nam (Korea Basic Science Institute)

07/12/2023, 12:20

The tumor microenvironment (TME) consisting of blood and lymphatic vessels, fibroblasts, immune cells, and extracellular matrix (ECM) is a critical factor determining prognosis of anti-cancer drug treatment. Most of all, vasculature and ECM structures are the most influential factors in TME. The abnormal, tortuous and leaky tumor vasculature structure reduces chemical drug delivery to target...